Zonisamide
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Zonisamide. Zonisamide is a benzisoxazole derivative. It inhibits sodium channels. Fully referenced neurology checklist.
Mode of action
- Zonisamide is a benzisoxazole derivative
- It inhibits sodium channels
- It reduces T-type calcium currents
Indications
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Dosing
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Neurological side effects
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Systemic side effects
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References
- Brodie MJ, Ben-Menachem E, Chouette I, Giorgi L. Zonisamide: its pharmacology, efficacy and safety in clinical trials. Acta Neurol Scand Suppl 2012; 194:19-28.
- Kwan SY, Chuang YC, Huang CW, Chen TC, Jou SB, Dash A. Zonisamide: review of recent clinical evidence for treatment of epilepsy. CNS Neurosci Ther 2015; 21:683-691.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Zaccara G, Specchio LM. Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature. Neuropsychiatr Dis Treat 2009; 5:249-259.
- Guerrini R, Rosati A, Segieth J, Pellacani S, Bradshaw K, Giorgi L. A randomized phase III trial of adjunctive zonisamide in pediatric patients with partial epilepsy. Epilepsia 2013; 54:1473-1480.
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