Acetazolamide

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Acetazolamide. Acetazolamide is a carbonic anhydrase inhibitor. Fully referenced neurology checklist.

Mode of action

  • Acetazolamide is a carbonic anhydrase inhibitor 
  • It acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
  • It is used as adjunct or monotherapy

Indications

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Dosing

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Side effects

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References

  1. Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother 1996; 30:514-519. 
  2. Vrielynck P. Current and emerging treatments for absence seizures in young patients. Neuropsychiatr Dis Treat 2013; 9:963-975.
  3. Resor SR Jr, Resor LD. Chronic acetazolamide monotherapy in the treatment of juvenile myoclonic epilepsy. Neurology 1990; 40:1677-1681.
  4. Hoddevik GH. Acetazolamide-are there reasons for its revival in antiepileptic treatment? Tidsskr Nor Laegeforen 2000; 120:1042-1045. 
  5. Vaamonde J, Legarda I, Jimenez-Jimenez J, Obeso JA. Acetazolamide improves action myoclonus in Ramsay Hunt syndrome. Clin Neuropharmacol 1992; 15:392-396.
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