Felbamate
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Felbamate. Felbamate inhibits GABA receptor binding. Fully referenced neurology checklist.
Mode of action
- Felbamate inhibits GABA receptor binding
- It may prevent generalisation of seizures by raising the seizure threshold
Indications
Locked: subscribe to see this section.
Dosing
Locked: subscribe to see this section.
Serious side effects
Locked: subscribe to see this section.
Neuropsychiatric side effects
Locked: subscribe to see this section.
Urinary side effects
Locked: subscribe to see this section.
Systemic side effects
Locked: subscribe to see this section.
Intermittent monitoring indices
Locked: subscribe to see this section.
References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Anon. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). The Felbamate Study Group in Lennox-Gastaut Syndrome. N Engl J Med 1993; 328:29-33.
- Zupanc ML, Roell Werner R, et al. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatr Neurol 2010; 42:396-403.
- Leppik IE, Dreifuss FE, Pledger GW, et al. Felbamate for partial seizures: results of a controlled clinical trial. Neurology 1991; 41:1785-1789.
- Shi LL, Dong J, Ni H, Geng J, Wu T. Felbamate as an add-on therapy for refractory epilepsy. Cochrane Database Syst Rev 2014; 7:CD008295.
- And 6 more. Subscribe to see the full list
