Piracetam
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Piracetam. Piracetam is a derivative of GABA. It influences neuronal membrane fluidity. Fully referenced neurology checklist.
Mechanism of action
- Piracetam is a derivative of GABA
- It influences neuronal membrane fluidity
- It acts by increasing the number of post-synaptic receptors
- It influences acetylcholine, glutamate, serotonin and noradrenaline
- It enhances the anticonvulsant effect of Valproate
Indications
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Dosing
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Contraindications
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Neuropsychiatric effects
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Systemic effects
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References
- Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev 2005; 11:169-182.
- Genton P, Guerrini R, Remy C. Piracetam in the treatment of cortical myoclonus. Pharmacopsychiatry 1999; 32(Suppl 1):49-53.
- Fedi M, Reutens D, Dubeau F, Andermann E, D'Agostino D, Andermann F. Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy. Arch Neurol 2001; 58:781-786.
- Hoshino A, Kumada S, Yokochi F, et al. Effects of piracetam therapy in a case of Lance-Adams syndrome. No To Hattatsu 2009; 41:357-360.
- Obeso JA, Artieda J, Rothwell JC, Day B, Thompson P, Marsden CD. The treatment of severe action myoclonus. Brain 1989; 112:765-777.
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