Rufinamide
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Rufinamide. Rufinamide inhibits high-frequency firing of sodium-dependent action potentials. Fully referenced neurology checklist.
Mode of action
- Rufinamide inhibits high-frequency firing of sodium-dependent action potentials
Indications (adjunctive)
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Dosing: adults
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Dosing: children ≥ 4 years
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Neuropsychiatric side effects
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Dermatological side effect: DRESS syndrome
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Systemic side effects
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References
- Brodie MJ, Rosenfeld WE, Vazquez B, et al. Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial. Epilepsia 2009; 50:1899-1909.
- Kluger G, Kurlemann G, Haberlandt E, Ernst JP, Runge U, Schneider F, Makowski C, Boor R, Bast T. Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience. Epilepsy Behav 2009; 14:491-495.
- Jaraba S, Santamarina E, Miró J, et al. Rufinamide in children and adults in routine clinical practice. Acta Neurol Scand 2017; 135:122-128.
- Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology 2008; 70:1950-1958.
- Wier HA, Cerna A, So TY. Rufinamide for pediatric patients with Lennox-Gastaut syndrome: a comprehensive overview. Paediatr Drugs 2011; 13:97-106.
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