Vigabatrin
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Vigabatrin. Vigabatrin blocks GABA transferase. Fully referenced neurology checklist.
Mode of action
- Vigabatrin blocks GABA transferase
Indications
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Dosing
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Ophthalmic side effects
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Neuropsychiatric side effects
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Systemic side effects
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Vigabatrin associated brain abnormalities (VABAM)
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Histological side effects
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Contraindications and precautions
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References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Koul R, Chacko A, Ganesh A, Bulusu S, Al Riyami K. Vigabatrin associated retinal dysfunction in children with epilepsy. Arch Dis Child 2001; 85:469-473.
- Iannetti P, Spalice A, Perla FM, Conicella E, Raucci U, Bizzarri B. Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics 2000; 106:838-842.
- Lahat E, Ben-Zeev B, Zlotnik J, Sela BA. Aminoaciduria resulting from vigabatrin administration in children with epilepsy. Pediatr Neurol 1999; 21:460-463.
- Gherpelli JL, Guerreiro MM, da Costa JC, et al. Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study. Epilepsy Res 1997; 29:1-6.
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