Multiple sclerosis (MS): seizures

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Multiple sclerosis (MS): seizures. Seizures occur in about 2-8% of people with MS. Fully referenced neurology checklist.

Epidemiology of seizures in MS

  • Seizures occur in about 2-8% of people with MS
  • The risk correlates with disease severity
  • The risk is also higher in those on SP1R modulating drugs

Risk factors

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Seizure focus in MS

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Presentation of seizures in MS

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References

  1. Sponsler JL, Kendrick-Adey AC. Seizures as a manifestation of multiple sclerosis. Epileptic Disord 2011; 13:401-410.
  2. Shaygannejad V, Ashtari F, Zare M, Ghasemi M, Norouzi R, Maghzi H. Seizure characteristics in multiple sclerosis patients. J Res Med Sci 2013; 18(Suppl 1):S74-S77.
  3. Kavčič A, Hofmann WE. Unprovoked seizures in multiple sclerosis: why are they rare? Brain Behav 2017; 7:e00726. 
  4. Burman J, Zelano J. Epilepsy in multiple sclerosis: a nationwide population-based register study. Neurology 2017; 89:2462-2468. 
  5. Pozzilli V, Haggiag S, Di Filippo M, et al. Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials. JNNP 2024; 95:612-619.
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