Multiple sclerosis (MS): classification
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Multiple sclerosis (MS): classification. Repeated demyelinating attacks affecting different CNS areas lasting >24 hours or.
Relapsing remitting MS (RRMS)
- Repeated demyelinating attacks affecting different CNS areas lasting >24 hours or
- One demyelinating attack with MRI or CSF features of dissemination in time and place
Primary progressive MS (PPMS)
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Secondary progressive MS (SPMS)
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Benign (non-progressive) MS
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Spinal onset MS
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Pure spinal MS
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Myelocortical MS
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Cortically dominant MS
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Oligoclonal band (OCB) negative MS
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Marburg variant
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Schilder’s disease (myelinoclastic diffuse sclerosis)
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Other forms and variants of MS
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References
- Selchen D, Bhan V, Blevins G, et al. MS, MRI, and the 2010 McDonald criteria: A Canadian expert commentary. Neurology 2012; 79:S1-S15.
- Zeydan B, Gu X, Atkinson EJ, et al. Cervical spinal cord atrophy: an early marker of progressive MS onset. Neurol Neuroimmunol Neuroinflamm 2018; 5:e435.
- Skoog B, Runmarker B, Winblad S, Ekholm S, Andersen O. A representative cohort of patients with non-progressive multiple sclerosis at the age of normal life expectancy. Brain 2012; 135:900-911.
- Skoog B, Runmarker B, Winbald S, Ekholm S, Andersen O. A representative cohort of patients with non-progressive multiple sclerosis at the age of normal life expectancy. Brain 2012; 135:900-911.
- Gajofatto A, Turatti M, Bianchi MR, et al. Benign multiple sclerosis: physical and cognitive impairment follow distinct evolutions. Acta Neurol Scand 2016; 133:183-191.
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Related checklists
- Multiple sclerosis (MS): revised McDonald diagnostic criteria
- Multiple sclerosis (MS): non-modifiable risk factors
- Multiple sclerosis (MS): modifiable risk factors
- Multiple sclerosis (MS): protective factors
- Multiple sclerosis (MS): typical neurological features
- Multiple sclerosis (MS): other neurological features
- Multiple sclerosis (MS): systemic features
- Multiple sclerosis (MS): paroxysmal attacks
- Multiple sclerosis (MS): seizures
- Multiple sclerosis (MS): differential diagnosis
- Multiple sclerosis (MS): clinical red flags against diagnosis
- Multiple sclerosis (MS): laboratory red flags against diagnosis
- Multiple sclerosis (MS): poor prognostic factors
- Multiple sclerosis (MS): smouldering associated worsening
