PARK8 genetic Parkinson's disease (PD)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

PARK8 genetic Parkinson's disease (PD). The transmission is autosomal dominant. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in the LRRK2 gene on chromosome 12q
  • The transmission is autosomal dominant
  • Aspirin and Ibuprofen may reduce the penetrance
  • Lewy bodies are present in some cases

Clinical features

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Treatment

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References

  1. Wszolek ZK, Pfeiffer B, Fulgham JR, et al. Western Nebraska family (family D) with autosomal dominant parkinsonism. Neurology 1995; 45:502-505.
  2. Paisán-Ruíz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004; 44:595-600.
  3. San Luciano M, Tanner CM, Meng C, et al. Nonsteroidal anti-inflammatory use and LRRK2 Parkinson's disease penetrance. Mov Disord 2020 (Online ahead of print).

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