PARK16 genetic Parkinson's disease (PD)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

PARK16 genetic Parkinson's disease (PD). This is probably associated with mutations in the LRRK2 or SNCA genes. Fully referenced neurology checklist.

Genetics

  • This is probably associated with mutations in the LRRK2 or SNCA genes
  • These are on chromosome 1q

References

  1. Satake W, Nakabayashi Y, Mizuta I, et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 2009; 41:1303-1307. 
  2. Simón-Sánchez J, Schulte C, Bras JM, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 2009; 41:1308-1312.
  3. Vilariño-Güell C, Ross OA, Aasly JO, et al. An independent replication of PARK16 in Asian samples. Neurology 2010; 75:2248-2249.

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