PARK11 genetic Parkinson's disease (PD)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

PARK11 genetic Parkinson's disease (PD). This is caused by mutations in the GIGYF2 gene on chromosome 2q. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in the GIGYF2 gene on chromosome 2q
  • The transmission is autosomal dominant

Clinical features

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References

  1. Pankratz N, Nichols WC, Uniacke SK, et al; Parkinson Study Group. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. Am J Hum Genet 2002; 71:124-135.
  2. Tan EK, Lin CH, Tai CH, et al. Non-synonymous GIGYF2 variants in Parkinson's disease from two Asian populations. Hum Genet 2009; 126:425-430.

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