PARK3 genetic Parkinson's disease (PD)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

PARK3 genetic Parkinson's disease (PD). This is caused by mutations on chromosome 2p. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations on chromosome 2p
  • The transmission is autosomal dominant

Clinical features

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Treatment

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References

  1. Gasser T, Müller-Myhsok B, Wszolek ZK, et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat Genet 1998; 18:262-265.
  2. DeStefano AL, Lew MF, Golbe LI, et al. PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study. Am J Hum Genet 2002; 70:1089-1095. 
  3. Karamohamed S, DeStefano AL, Wilk JB, et al; GenePD study. A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study. Neurology 2003; 61:1557-1561.

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