Alzheimer’s disease (AD): clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Alzheimer’s disease (AD): clinical features. Alzheimer’s disease is an irreversible neurodegenerative disorder of the brain.

Definition

  • Alzheimer’s disease is an irreversible neurodegenerative disorder of the brain
  • It results in impaired brain function
  • It results in cognitive and functional decline

Memory difficulties

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Language difficulties

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Praxis difficulties

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Visuospatial difficulties

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Executive dysfunction

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Other cognitive features

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Non-cognitive features

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Features of young-onset AD

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Differential diagnosis

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Acronym

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References

  1. Grecius MD, Geschwind MD, Miller BL. Presenile dementia syndromes: an update on taxonomy and diagnosis. JNNP 2002; 72:691-700.
  2. Rajan KB, Wilson RS, Weuve J, Barnes LL, Evans DA. Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia. Neurology 2015; 85:898-904.
  3. Rossor MN, Fox NC, Mummery CJ, Schott JN, Warren JD. The diagnosis of young-onset dementia. Lancet Neurol 2010; 9:793-806.
  4. Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.
  5. Atri A. The Alzheimer's disease clinical spectrum: diagnosis and management. Med Clin North Am 2019; 103:263-293.
  6. And 16 more. Subscribe to see the full list

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