Ross syndrome
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Ross syndrome. This is a disorder of thermoregulation. Fully referenced neurology checklist.
Pathology
- This is a disorder of thermoregulation
- There is degeneration of cholinergic sudomotor and cutaneous sensory nerves
- This causes loss of sweating and impaired heat production and heat dissipation
- There is also loss of cutaneous blood flow regulation
Clinical features
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Associations
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Differential diagnosis
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Treatment
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References
- Nolano M, Provitera V, Perretti A, et al. Ross syndrome: a rare or a misknown disorder of thermoregulation? A skin innervation study on 12 subjects. Brain 2006; 129:2119-2131.
- Sommer C, Lindenlaub T, Zillikens D, Toyka KV, Naumann M. Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome. Ann Neurol 2002; 52:247-250.
- Bergmann I, Dauphin M, Naumann M, et al. Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin. Muscle Nerve 1998; 21:1790-1793.
- Drummond PD, Edis RH. Loss of facial sweating and flushing in Holmes-Adie syndrome. Neurology 1990; 40:847-849.
- Agarwala MK, George L, Parmar H, Mathew V. Ross syndrome: a case report and review of cases from India. Indian J Dermatol 2016; 61:348.
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