Anisocoria

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anisocoria. This is a difference of ≥ 0.4mm in pupillary diameters. Fully referenced neurology checklist.

Definition

  • This is a difference of ≥ 0.4mm in pupillary diameters
  • It is due to mydriasis if it is worse in bright light
  • It is due to miosis if it is worse in the dark

Pharmacological causes of unilateral mydriasis

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Ophthalmic causes of unilateral mydriasis

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Neurological causes of unilateral mydriasis

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Toxic causes of unilateral mydriasis

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Iatrogenic causes of unilateral mydriasis

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Other causes of unilateral mydriasis

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Causes of unilateral miosis

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References

  1. Evans RW, Jacobson DM. Transient anisocoria in a migraineur. Headache 2003; 43:416-418. 
  2. Heath Jeffery RC, Young B, Swann PG, Lueck CJ. Unequal pupils: understanding the eye's aperture. Aust J Gen Pract 2019; 48:39-42.
  3. Ekici A, Caglar B, Kara O, Oto A, Kilic N. Rare causes of anisocoria: Ipratropium bromide and Angel's trumpet. North Clin Istanb 2021; 8:623-625.
  4. Garstad LJ, Mygland Å, Ljøstad U. A woman in her 40s with anisocoria and unilateral facial flushing. Tidsskr Nor Laegeforen 2017; 137:40-42.
  5. Shah J, Jiang A, Fekete Z. Anisocoria secondary to inadvertent contact with scopolamine patch. BMJ Case Rep 2017; 2017:bcr2017221677.
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