Holmes-Adie syndrome (HAS)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Holmes-Adie syndrome (HAS). Tonic pupils, Near-light dissociation, Areflexia. Fully referenced neurology checklist.
Diagnostic triad
- Tonic pupils
- Near-light dissociation
- Areflexia
Pathology
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Ophthalmic features
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Neurological features
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Autonomic features
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Differential diagnosis: secondary causes of tonic pupils
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Investigation: dilute pilocarpine test
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Treatment
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Synonym
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References
- Kimber J, Mitchell D, Mathias CJ. Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction. JNNP 1998; 65:583-586.
- Xu SY, Song MM, Li L, Li CX. Adie's pupil: a diagnostic challenge for the physician. Med Sci Monit 2022; 28:e934657.
- Colak S, Erdogan MO, Senel A, et al. A rare case in the emergency department: Holmes-Adie Syndrome. Turk J Emerg Med 2016; 15:40-42.
- Bacon PJ, Smith SE. Cardiovascular and sweating dysfunction in patients with Holmes-Adie syndrome. JNNP 1993; 56:1096-1102.
- Mak W, Cheung RT. The Holmes-Adie plus syndrome. J Clin Neurosci 2000; 7:452.
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