Harlequin syndrome

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Harlequin syndrome. This is an autonomic disorder. Fully referenced neurology checklist.

Pathology

  • This is an autonomic disorder
  • It is caused by dysfunction of the upper thoracic sympathetic chain

Clinical features

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Associated disorders

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Neurological causes

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Iatrogenic causes

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Neoplastic causes

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Vascular causes

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Other causes

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Investigations

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Treatments

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References

  1. Pradeep PV, Benede AK, Harshita SS, Jayashree B. Harlequin syndrome in a case of toxic goitre: a rare association. Case Rep Med 2011; 2011:293076. 
  2. Algahtani H, Shirah B, Algahtani R, Alkahtani A. Idiopathic harlequin syndrome manifesting during exercise: a case report and review of the literature. Case Rep Med 2017; 2017:5342593.
  3. Naqvi SY, Zainal A, Flood SP, Kinniry P. Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. BMJ Case Rep 2016; 2016 pii: bcr2016216931.
  4. Mavroudis I, Balmus IM, Ciobica A, et al. Mini-review on the harlequin syndrome - a rare dysautonomic manifestation requiring attention. Medicina (Kaunas) 2022; 58:938.
  5. Vidal Esteban A, Natera-de Benito D, Martínez Sánchez D, et al. Congenital Harlequin syndrome as an isolated phenomenon: A case report and review of the literature. Eur J Paediatr Neurol 2016; 20:426-430.
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