Oxaliplatin induced neuropathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Oxaliplatin induced neuropathy. Oxaliplatin causes cold -triggered paraesthesias or dysesthesias. Fully referenced neurology checklist.
Acute neurotoxicity
- Oxaliplatin causes cold -triggered paraesthesias or dysesthesias
- These develop immediately after infusion
- They affect the distal extremities or perioral region
- There are pharyngolaryngeal dysesthesias in some cases
- There may be associated tetanic spasms
- Fasciculations may be evident
- There may be muscle contractions of the extremities or the jaw
Cumulative neurotoxicity
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Management
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Outcome
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References
- Velasco R, Bruna J, Briani C, Argyriou AA, et al. Early predictors of oxaliplatin-induced cumulative neuropathy in colorectal cancer patients. JNNP 2014; 85:392-398.
- Saif MW, Reardon J. Management of oxaliplatin-induced peripheral neuropathy. Ther Clin Risk Manag 2005; 1:249-258.
- Briani C, Argyriou AA, Izquierdo C, et al. Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study. J Peripher Nerv Syst 2014; 19:299-306.
