Bortezomib induced neuropathy:
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Bortezomib induced neuropathy. Bortezomib is a proteosome inhibitor. It is used to treat multiple myeloma relapse. Fully referenced neurology checklist.
Features
- Bortezomib is a proteosome inhibitor
- It is used to treat multiple myeloma relapse
- It gives rise to a small fiber distal sensory axonal neuropathy
- The neuropathy develops within the first treatment cycles
- It plateaus by the fifth cycle with no further progression
Risk factors
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Presentations
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References
- Sonneveld P, Jongen JLM. Dealing with neuropathy in plasma-cell dyscrasia. Hematology Am Soc Hematol Educ Program 2010; 2010:423-430.
- Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst 2008; 13:27-46.
- Mohty B, El-Cheikh J, Yakoub-Agha I, Moreau P, Harousseau JL. Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations. Haematologica 2010; 95:311-319.
