Epothilones induced neuropathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Epothilones induced neuropathy. Patupilone (epothilone B), Desoxyepothilone A (epothilone C). Fully referenced neurology checklist.
Types
- Ixabepilone: this is an epothilone B analogue: it is representative of the drugs
- Patupilone (epothilone B)
- Desoxyepothilone A (epothilone C)
- Desoxyepothilone B (epothilone D)
- Sagopilone
Mode of action
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Indications: advanced cancer types
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Risk factors for neuropathy
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Neuropathy features
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Other features
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Synonym
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References
- Vahdat LT, Thomas ES, Roché HH, et al. Ixabepilone-associated peripheral neuropathy: data from across the phase II and III clinical trials. Support Care Cancer 2012; 20:2661-2668.
- Rivera E, Lee J, Davies A. Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors. Oncologist 2008; 13:1207-1223.
- Argyriou AA, Marmiroli P, Cavaletti G, Kalofonos HP. Epothilone-induced peripheral neuropathy: a review of current knowledge. J Pain Symptom Manage 2011; 42:931-940.
- Goel S, Goldberg GL, Kuo DY, Muggia F, Arezzo J, Mani S. Novel neurosensory testing in cancer patients treated with the epothilone B analog, ixabepilone. Ann Oncol 2008; 19:2048-2052.
- Bosch-Barrera J, Espinós J, Gómez-Ibáñez A, Gállego Pérez-Larraya J, Iriarte J. Sensory-motor axonal peripheral neuropathy in an advanced breast cancer patient treated with ixabepilone. Clin Transl Oncol 2009; 11:765-767.
