Antimetabolites induced neuropathy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Antimetabolites induced neuropathy. Methotrexate is a folate antagonist: it is not usually neurotoxic. Fully referenced neurology checklist.
Antimetabolite drugs
- Methotrexate is a folate antagonist: it is not usually neurotoxic
- 5-Fluorouracil is a pyrimidine antagonist: peripheral neuropathy occurs rarely
- Cytosine arabinoside (Ara-C) is a pyrimidine antagonist: it is not usually neurotoxic
- Gemcitabine is a deoxycytidine analogue: it causes sensory neuropathy in 10% of cases
- Cepecitabine causes palmar plantar erythrodysesthesia (hand-foot syndrome)
