Autoimmune encephalitis: antibodies
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Autoimmune encephalitis: antibodies. AK5, AMPAR, Aquaporin 4, CASPR2, CRMP5/CV2, DPPX, GABA, GAD65, GQ1b, Hu, IgLON5. Fully referenced neurology checklist.
Major antibodies
- AK5
- AMPAR
- Aquaporin 4
- CASPR2
- CRMP5/CV2
- DPPX
- GABA
- GAD65
- GQ1b
- Hu
- IgLON5
- KLHL11
- LGI1
- Ma1
- Ma2
- mGluR5
- MOG
- Neuraxin-3α
- NMDAR
- PD10A
- PR2
- Ri
Rare antibodies
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References
- Abboud H, Probasco JC, Irani S, et al. Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management. JNNP 2021; 92:757-768.
- Levite M. Glutamate receptor antibodies in neurological diseases J Neural Transm (Vienna) 2014; 121:1029-1075.
- Graus F, Titulaer MJ, Balu R et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 2016; 15:391-404.
- Ganor Y, Goldberg-Stern H, Blank M, et al. Antibodies to glutamate receptor subtype 3 (GluR3) are found in some patients suffering from epilepsy as the main disease, but not in patients whose epilepsy accompanies antiphospholipid syndrome or Sneddon's syndrome. Autoimmunity 2005; 38:417-424.
- Goldberg-Stern H, Ganor Y, Cohen R, Pollak L, Teichberg V, Levite M. Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) associate with some cognitive/psychiatric/behavioral abnormalities in epilepsy patients. Psychoneuroendocrinology 2014; 40:221-31.
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