Segmental arterial mediolysis (SAM)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Segmental arterial mediolysis (SAM). This is a nonatherosclerotic, non-inflammatory vasculopathy. Fully referenced neurology checklist.
Pathology
- This is a nonatherosclerotic, non-inflammatory vasculopathy
- It may also affect coronary and abdominal arteries
- It may potentially be triggered by acute physiological stress
- It may be associated with Ehlers Danlos syndrome type IV
- It may also be related to COL3A1 mutations
Clinical presentations
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Differential diagnoses
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Investigations
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References
- Delafosse E, Armengol G, Triquenot-Bagan A, Hebant B. A case of segmental arterial mediolysis with widespread involvement of cranial and abdominal arteries. J Neurol Sci 2019; 397:81-83.
- Welch BT, Brinjikji W, Stockland AH, Lanzino G. Subarachnoid and intraperitoneal hemorrhage secondary to segmental arterial mediolysis: a case report and review of the literature. Interv Neuroradiol 2017; 23:378-381.
- Shinoda N, Hirai O, Mikami K, et al. Segmental arterial mediolysis involving both vertebral and middle colic arteries leading to subarachnoid and intraperitoneal hemorrhage. World Neurosurg 2016; 88:694.e5-e10.
- Sethi A, Hyde JR, Thaler CM, Skeik N. Extensive cerebrovascular and visceral artery dissection and pseudoaneurysm with underlying segmental arterial mediolysis. Ann Vasc Surg 2017; 44:422.e9-422.e13.
Related checklists
- Cantu syndrome
- Fibromuscular dysplasia (FMD)
- Subclavian steal syndrome
- Intracranial artery stenosis (ICAS)
- Vertebral artery stenosis (VAS)
- Cerebral proliferative angiopathy (CPA)
- Arterial tortuosity syndrome (ATS)
- Retinal vasculopathy with cerebral leukoencephalopathy (RVCL): clinical features
- Cervical internal carotid artery vasospasm (CICAV)
