Cerebral proliferative angiopathy (CPA)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebral proliferative angiopathy (CPA). This is a brain vascular malformation. Fully referenced neurology checklist.

Pathology

  • This is a brain vascular malformation
  • Abnormal vascular channels are interspersed in functional brain parenchyma
  • It results from uncontrolled angiogenesis
  • There is a proliferative nidus
  • Most are supratentorial but some are infratentorial

Pathological features

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Demographic features

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Clinical features

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Complications

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Differential diagnosis

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Magnetic resonance imaging (MRI) brain

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Cerebral angiogram

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Treatment

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References

  1. Palavani LB, Mitre LP, Almeida MV, et al. Presentation and management of cerebral proliferative angiopathy: a systematic review and meta-analysis on treatment outcomes. Neurosurg Rev 2024; 47:664.
  2. Hess RM, Zhang JF, Cappuzzo JM, Bregy A, Levy EI. Cerebral proliferative angiopathy presenting as subdural hematoma: a case report and systematic literature review. World Neurosurg 2022; 164:281-289.
  3. Kumar S, Sharma M, Srivastava T, Sinha VD. Infratentorial hemorrhagic cerebral proliferative angiopathy: A rare presentation of a rare disease. Asian J Neurosurg 2015; 10:240-242.
  4. Yamaki VN, Solla DJF, Telles JPM, et al. The current clinical picture of cerebral proliferative angiopathy: systematic review. Acta Neurochir (Wien) 2020; 162:1727-1733.
  5. Srivastava T, Gandhi A, Kumar R. Clinico-radiological features of cerebral proliferative angiopathy: a large case series from India. Neuroradiol J 2022; 35:742-750.
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