Riluzole
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Riluzole. Riluzole is a benzothiazole derivative. It inhibits presynaptic glutamate release. Fully referenced neurology checklist.
Pharmacology
- Riluzole is a benzothiazole derivative
- It inhibits presynaptic glutamate release
- It is indicated for both ALS and PMA
Benefits
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Dosing and administration
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Monitoring
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Side effects
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Acronyms
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References
- Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies. Neurology 2009; 73:1228-1226.
- Miller RG, Jackson CE, Kasarskis RJ, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioural impairment (an evidence-based review). Neurology 2009; 73:1227-1233.
- Leigh PN, Abrahams S, Al-Chalabi A, et al. The management of motor neurone disease. JNNP 2003; 74(Suppl IV):iv32-iv47.
- Mazumder S, McCann H, D'Silva S, et al. Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis. Brain 2023; 146:e17-e19.
- Thakore NJ, Lapin BR, Mitsumoto H, Pooled Resource Open-Access ALS Clinical Trials Consortium. Early initiation of riluzole may improve absolute survival in amyotrophic lateral sclerosis. Muscle Nerve 2022; 66:702-708.
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