Motor neurone disease (MND): neurological symptomatic treatments
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Motor neurone disease (MND): neurological symptomatic treatments. Baclofen 10-80 mg daily, Tizanidine 6–24 mg daily. Fully referenced neurology checklist.
Spasticity
- Baclofen 10-80 mg daily
- Tizanidine 6–24 mg daily
- Dantrolene 25–100 mg daily
- Memantine 10–60 mg daily
- Nabiximols: investigational
Cramps
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Labile emotion
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Pain
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Anxiety
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Fatigue
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Insomnia
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References
- Leigh PN, Abrahams S, Al-Chalabi A, et al. The management of motor neurone disease. JNNP 2003; 74(Suppl IV):iv32-iv47.
- Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies. Neurology 2009; 73:1228-1226.
- Wood-Allum C, Shaw PJ. Motor neurone disease: a practical update on diagnosis and management. Clin Med 2010; 10:252-258.
- Radunović A, Mitsumoto H, Leigh PN. Clinical care of patients with amyotrophic lateral sclerosis. Lancet Neurol 2007; 6:913-925.
- The Excerpta Medica MND Advisory Group. Guidelines for the management of motor neurone disease (MND). June 1999.
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