Restless legs syndrome (RLS): risk factors and causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Restless legs syndrome (RLS): risk factors and causes. Women, Pregnancy, North Europeans, North Americans, Obesity. Fully referenced neurology checklist.

Epidemiological risk factors

  • Women
  • Pregnancy
  • North Europeans
  • North Americans
  • Obesity

Peripheral neurological causes

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Central neurological causes

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Systemic causes

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Exacerbating drugs

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References

  1. Gao X, Schwarzschild MA, Wang H, Ascherio A. Obesity and restless legs syndrome in men and women. Neurology 2009; 72:1255-1261.
  2. Leschziner G, Gringras P. Restless legs syndrome. BMJ 2012;344:e3056.
  3. Bhidayasiri R, Waters MF, Giza CC. Neurological Differential Diagnosis. A Prioritized Approach. Blackwell publishing Massachusetts 2005 p234.
  4. Chen SJ, Shi L, Bao YP, et al. Prevalence of restless legs syndrome during pregnancy: a systematic review and meta-analysis. Sleep Med Rev 2018; 40:43-54. 
  5. Siemenski M, Bilinska M, Nyka WM. Increased frequency of restless legs syndrome in myasthenia gravis. Eur Neurol 2012; 68:166-170. 
  6. And 16 more. Subscribe to see the full list

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