Restless legs syndrome (RLS): drug treatments

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Restless legs syndrome (RLS): drug treatments. Pramipexole 0.125mg daily; maximum 0.75mg daily. Fully referenced neurology checklist.

Level A evidenced drug treatment

  • Pramipexole 0.125mg daily; maximum 0.75mg daily
  • Gabapentin enacarbil 600-1200mg daily
  • Rotigotine patch 1mg daily; maximum is 3mg daily
  • Cabergoline: this has significant cardiac side effects

Level B evidenced drug treatment

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Level C evidenced drug treatment

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Optional drug treatments: Gabapentin

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Optional drug treatments: others

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Guidelines for iron therapy

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Insufficient evidenced treatments

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Investigational treatments

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Acronyms

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References

  1. Leschziner G, Gringras P. Restless legs syndrome. BMJ 2012; 344:e3056.
  2. Symvoulakis E, Anyfantakis D, Lionis C. Restless legs syndrome: literature review. Sao Paulo Med J 2010; 128:167-170.
  3. Trenkwalder C, Paulus W, Walters AS. The restless legs syndrome. Lancet Neurol 2005; 4:465-475.
  4. Aurora RN, Kristo DA, Bista SR, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults-an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses. Sleep 2012; 35:1039-1062.
  5. Trenkwalder C, Hening WA, Mintagna P, et al. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Mov Disord 2008; 23:2267-2302.
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