Restless legs syndrome (RLS): drug related complications

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Restless legs syndrome (RLS): drug related complications. RLS symptoms starts earlier. They are more severe. Fully referenced neurology checklist.

Augmentation: features

  • RLS symptoms starts earlier
  • They are more severe
  • They spread to the arms
  • There are breakthrough symptoms at night
  • They worsen with increased drug dose

Augmentation: risk factors

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Other drug related complications

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References

  1. Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med 2016; 21:1-11. 
  2. Heim B, Djamshidian A, Heidbreder A, et al. Augmentation and impulsive behaviors in restless legs syndrome. Neurology 2016; 87:36-40.
  3. Chokroverty S. Long-term management issues in restless legs syndrome. Mov Disord 2011; 26:1378-1385.

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