Neuromyelitis optica spectrum disorder (NMOSD): peripheral neurological features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Neuromyelitis optica spectrum disorder (NMOSD): peripheral neurological features. Flaccid paralysis. Fully referenced neurology checklist.

Neuromuscular features

  • Flaccid paralysis
  • Lumbosacral radiculopathy
  • HyperCKemia
  • Myopathy
  • Rhabdomyolysis
  • Dysautonomia

Myasthenia gravis (MG)

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Neurophysiological features

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References

  1. Grüter T, Ayzenberg I, Gahlen A, Kneiphof J, Gold R, Kleiter I. Flaccid paralysis in neuromyelitis optica: an atypical presentation with possible involvement of the peripheral nervous system. Mult Scler Relat Disord 2018; 25:83-86. 
  2. Kim S, Kwon B, Park J, Lee H, Kim H, Park D, Nam K. Neuromyelitis optica masquerading as lumbosacral radiculopathy: a case report. Ann Rehabil Med 2016; 40:943-948.
  3. Abkur TM, Foran E, Kearney H, Harkin G, Byrnes V, Lynch J. Neuromyelitis optica presenting as intractable vomiting and hyperCKaemia. J Neurol 2016; 263:171-173.
  4. Malik R, Lewis A, Cree BA, et al. Transient hyperckemia in the setting of neuromyelitis optica (NMO). Muscle Nerve 2014; 50:859-862.
  5. Shouman K, Prieto PG, Stino AM, Lisak RP. Serum creatine kinase in patients with neuromyelitis optica spectrum disorder. J Neuroimmunol 2019; 330:87-89.
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