Multiple sclerosis (MS): ophthalmological tests

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Multiple sclerosis (MS): ophthalmological tests. These are asymmetrically abnormal in 42-100% of cases. Fully referenced neurology checklist.

Visual evoked potentials (VEPs)

  • These are asymmetrically abnormal in 42-100% of cases
  • They have a high sensitivity if the latencies differ by >6ms

Causes of symmetrically abnormal VEPs

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Other evoked potentials

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Optical coherence tomography (OCT)

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Trans-orbital ultrasound

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References

  1. Palace J. Making the diagnosis of multiple sclerosis. JNNP 2001; 71(suppl II):ii3-ii8.
  2. Toosy AT, Naismith RT, Villoslada P. OCT as a window to the MS brain: The view becomes slightly clearer. Neurology 2017; 89:2404-2405.
  3. Xu SC, Kardon RH, Leavitt JA, Flanagan EP, Pittock SJ, Chen JJ. Optical coherence tomography is highly sensitive in detecting prior optic neuritis. Neurology 2019; 92:e527-e535.
  4. Villoslada P, Sanchez-Dalmau B, Galetta S. Optical coherence tomography: a useful tool for identifying subclinical optic neuropathy in diagnosing multiple sclerosis. Neurology 2020; 95:239-240.
  5. Outteryck O, Lopes R, Drumez É, et al. Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome. Neurology 2020; 95:e733-e744.
  6. And 4 more. Subscribe to see the full list

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