Multiple sclerosis (MS): general investigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Multiple sclerosis (MS): general investigations. Full blood count, Inflammatory markers, Renal function tests. Fully referenced neurology checklist.

Baseline investigations

  • Full blood count
  • Inflammatory markers
  • Renal function tests
  • Liver function tests
  • Calcium
  • Blood glucose
  • Thyroid function tests
  • Vitamin B12 level

Serology

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Anti MOG antibody

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Epstein-Barr virus (EBV) antibodies

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Other autoantibodies

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Metabolic tests

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Electrocardiogram (ECG) for QTc analysis

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Other general tests

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References

  1. Scolding N. The differential diagnosis of multiple sclerosis. JNNP 2001; 71(Suppl 2):ii9-15.
  2. Multiple sclerosis: management of multiple sclerosis in primary and secondary care. NICE clinical guidelines [CG186]. October 2014.
  3. Perry M, Swain S, Kemmis-Betty S, Guideline Development Group of the National Institute for Health and Care Excellence. Multiple sclerosis: summary of NICE guidelines. BMJ 2014; 349:g5701.
  4. Spadaro M, Gerdes LA, Krumbholz M, et al. Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2016; 3:e257.
  5. Vietzen H, Kühner LM, Berger SM, et al. Epstein-Barr virus antibodies to differentiate multiple sclerosis from other neuroinflammatory diseases. JAMA Neurol 2026; 83:461-470.
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