Multiple sclerosis (MS): magnetic resonance imaging (MRI): protocol

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Multiple sclerosis (MS): magnetic resonance imaging (MRI): protocol. Investigation of clinically suspected MS. Fully referenced neurology checklist.

Indications for MRI in MS

  • Investigation of clinically suspected MS
  • Monitoring of confirmed MS
  • Monitoring of clinically isolated syndrome (CIS)
  • Monitoring of radiologically isolated syndrome (RIS)
  • Assessment before and after treatment changes
  • Assessment of clinical relapse
  • Assessment of suspected pseudo-relapses
  • Investigation of unexpected clinical worsening
  • Assessment of suspected progressive multifocal leukoencephalopathy (PML)

Indications for MRI imaging of the spinal cord

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MRI follow up: protocol

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MRI follow up: indications for more frequent imaging

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MRI follow up: protocol in CIS

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Recommended MRI sequences: diagnostic

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Recommended MRI sequences: follow up

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MRI equipment requirements

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MRI contrast administration guidelines

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References

  1. Vågberg M, Axelsson M, Birgander R, et al. Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society. Acta Neurol Scand 2017; 135:17-24. 
  2. Rovira À, Wattjes MP, Tintoré M, et al; MAGNIMS study group. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process. Nat Rev Neurol 2015; 11:471-482. 
  3. Karimian-Jazi K, Wildemann B, Diem R, et al. Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI. Neurol Neuroimmunol Neuroinflamm 2018; 5:e480.

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