Limbic predominant age related TDP-43 encephalopathy (LATE): pathology

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Limbic predominant age related TDP-43 encephalopathy (LATE): pathology. TMEM106B, GRN, ABCC9, KCNMB2, APOE. Fully referenced neurology checklist.

Genetic risk variants

  • TMEM106B
  • GRN
  • ABCC9
  • KCNMB2
  • APOE

Neuropathological changes (LATE-NC)

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References

  1. Hokkanen SRK, Kero M, Kaivola K, et al. Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain Pathol 2020; 30:364-372.
  2. Nelson PT, Dickson DW, Trojanowski JQ, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 2019; 142:1503-1527.
  3. Besser LM, Teylan MA, Nelson PT. Limbic predominant age-related TDP-43 encephalopathy (LATE): clinical and neuropathological associations. J Neuropathol Exp Neurol 2020; 79:305-313.
  4. Gauthreaux KM, Teylan MA, Katsumata Y, et al. Limbic-predominant age-related TDP-43 encephalopathy: medical and pathologic factors associated with comorbid hippocampal sclerosis. Neurology 2022; 98:e1422-e1433. 

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