Limbic predominant age related TDP-43 encephalopathy (LATE): differential diagnosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Limbic predominant age related TDP-43 encephalopathy (LATE): differential diagnosis. AD has more executive and visuospatial impairments.
Alzheimer’s disease
- Alzheimer’s disease (AD) is more likely to manifest language impairment
- AD has more executive and visuospatial impairments
- AD progresses faster than LATE
- Life expectancy is shorter tin AD that in LATE
- Amyloid and tau imaging are negative in ALATE
- CSF amyloid and phosphorylated tau are normal in LATE
Other differentials
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References
- Nelson PT, Schneider JA, Jicha GA, Duong MT, Wolk DA. When Alzheimer's is LATE: Why Does it Matter? Ann Neurol 2023 (Online ahead of print).
- Butler Pagnotti RM, Pudumjee SB, Cross CL, Miller JB. Cognitive and clinical characteristics of patients with limbic-predominant age-related TDP-43 encephalopathy. Neurology 2023; 100:e2027-e2035.
- Robinson JL, Porta S, Garrett FG, et al. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration. Brain 2020 (Online ahead of print).
