Limbic predominant age related TDP-43 encephalopathy (LATE): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Limbic predominant age related TDP-43 encephalopathy (LATE): clinical features. TMEM106B, GRN, ABCC9, KCNMB2, APOE. Fully referenced neurology checklist.
Genetic risk variants
- TMEM106B
- GRN
- ABCC9
- KCNMB2
- APOE
Epidemiological features
Locked: subscribe to see this section.
Clinical features
Locked: subscribe to see this section.
Associated disorders
Locked: subscribe to see this section.
Neuropathological change (LATE-NC)
Locked: subscribe to see this section.
Course and progression
Locked: subscribe to see this section.
References
- Nelson PT, Dickson DW, Trojanowski JQ, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 2019; 142:1503-1527.
- Cho SH, Choi SM, Kim BC, Song WY, Kim HS, Lee KH. An autopsy-proven case of limbic-predominant age-related tdp-43 encephalopathy. Yonsei Med J 2020; 61:731-735.
- Di J, Nelson RS, Jicha GA, et al. Urinary incontinence in a community-based autopsy cohort is associated with limbic predominant age-related TDP-43 encephalopathy neuropathologic changes. J Alzheimers Dis 2023; 94:333-346.
- Uemura MT, Robinson JL, Cousins KAQ, et al. Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease. Acta Neuropathol 2022; 143:15-31.
- Hokkanen SRK, Kero M, Kaivola K, et al. Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain Pathol 2020; 30:364-372.
- And 7 more. Subscribe to see the full list
