Hypereosinophilic syndrome
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Hypereosinophilic syndrome. This is a clonal myeloproliferative disorder. Fully referenced neurology checklist.
Pathology
- This is a clonal myeloproliferative disorder
- It is caused by mutations in the FIP1L1 and PDGFRA genes on chromosome 4q
- There is eosinophilia >1.5 x 10(9)/L for > 6 months
- It causes eosinophil-induced organ damage
- The onset is from young to middle age
- There is a male predominance
General features
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Systemic features
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Central nervous system features
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Peripheral nervous system features
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Differential diagnosis
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References
- Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007; 2:37.
- Titlić M, Kodzoman K, Loncar D. Neurologic manifestations of hypereosinophilic syndrome-review of the literature. Acta Clin Croat 2012; 51:65-69.
- Moore PM, Harley JB, Fauci AS. Neurologic dysfunction in the idiopathic hypereosinophilic syndrome. Ann Intern Med 1985; 102:109-114.
- Liu Y, Meng X, Feng J, Zhou X, Zhu H. Hypereosinophilia with concurrent venous thromboembolism: clinical features, potential risk factors, and short-term outcomes in a Chinese cohort. Sci Rep 2020; 10:8359.
- Wasilewski A. Teaching NeuroImages: Multifocal cerebral infarcts as a presentation of idiopathic hypereosinophilic syndrome. Neurology 2019; 92:e2178.
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