Common variable immunodeficiency (CVID)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Common variable immunodeficiency (CVID). CVID is a primary immunodeficiency disorder, Immunoglobulin levels are low. Fully referenced neurology checklist.
Pathology
- CVID is a primary immunodeficiency disorder
- Immunoglobulin levels are low
- Antibody production is low or absent
Intracranial neurological features
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Ophthalmic features
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Spinal neurological features
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Peripheral neurological features
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Systemic features
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Radiological features
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Cerebrospinal fluid (CSF) analysis
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Brain pathological features
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References
- De Almeida BI, Smith TL, Delic A, et al. Neurologic manifestations of common variable immunodeficiency: impact on quality of life. Neurol Neuroimmunol Neuroinflamm 2023; 10:e200088.
- Nguyen T, McCauley M, Zheng T, Rizvi SA. Common variable immunodeficiency presenting as anti-GAD cerebellar ataxia. R I Med J (2013) 2020; 103:38-39.
- Najem CE, Springer J, Prayson R, et al. Intra cranial granulomatous disease in common variable immunodeficiency: Case series and review of the literature. Semin Arthritis Rheum 2018; 47:890-896.
- Martins B, Miranda J, Pinto MJ, et al. Common variable immunodeficiency and its inflammatory neurological manifestations: a case report and literature review. Mult Scler Relat Disord 2022; 67:104086.
- Nguyen JT, Green A, Wilson MR, DeRisi JL, Gundling K. Neurologic Complications of Common Variable Immunodeficiency. J Clin Immunol 2016; 36:793-800.
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