Bing-Neel syndrome (BNS)

Pathology

• This is central nervous system involvement by Waldenstrom’s macroglobulinaemia (WM)
• It results from infiltration by malignant lymphoid cells
• It is the first manifestation of WM in more than a third of cases

References

1. Simon L, Fitsiori A, Lemal R, et al. Bing-Neel syndrome, a rare complication of Waldenström macroglobulinemia: analysis of 44 cases and review of the literature. A study on behalf of the French Innovative Leukemia Organization (FILO). Haematologica 2015; 100:1587-1594.
2. Varettoni M, Defrancesco I, Diamanti L, Marchioni E, Farina LM, Pichiecchio A. Bing-Neel syndrome: illustrative cases and comprehensive review of the literature. Mediterr J Hematol Infect Dis 2017; 9:e2017061. 
3. Bhatti MT, Yuan C, Winter W, McSwain AS, Okun MS. Bilateral sixth nerve paresis in the Bing-Neel syndrome. Neurology 2005; 64:576-577.
4. Welch D, Whetsell WO Jr, Weil RJ. Pathologic quiz case. A man with long-standing monoclonal gammopathy and new onset of confusion. Central nervous system involvement by Waldenström macroglobulinemia-Bing-Neel syndrome. Arch Pathol Lab Med 2002; 126:1243-1244. 
5. Sobczak T, Alleman L, Wille H, et al. Recurrent meningitis revealing a Bing-Neel syndrome. Rev Med Interne 2021; 42:359-362. 
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