Hereditary spastic paraplegia type 41 (SPG41)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hereditary spastic paraplegia type 41 (SPG41). This is caused by mutations in chromosome 11p. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in chromosome 11p
  • The transmission is autosomal dominant
  • It usually presents as pure HSP
  • The mean onset age is about 16 years

Clinical features

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References

  1. Zhao GH, Hu ZM, Shen L, et al. A novel candidate locus on chromosome 11p14.1-p11.2 for autosomal dominant hereditary spastic paraplegia. Chin Med J (Engl) 2008; 121:430-434. 

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