Anti-synthetase syndrome
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-synthetase syndrome. Myositis, Interstitial lung disease (ILD), Non-erosive arthropathy. Fully referenced neurology checklist.
Major triad
- Myositis
- Interstitial lung disease (ILD)
- Non-erosive arthropathy
Mechanics hands
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Other clinical features
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Reported associations
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Investigations: anti-aminoacyl-tRNA synthetase antibodies
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Investigations: others
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Treatment
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References
- Mammen AL. Dermatomyositis and polymyositis: clinical presentation, autoantibodies, and pathogenesis. Ann N Y Acad Sci 2010; 1184:134-153.
- Katzap E, Barilla-LaBarca ML, Marder G. Antisynthetase syndrome. Curr Rheumatol Rep. 2011; 13:175-181.
- Bandeira M, Dourado E, Melo AT, et al. Mechanic's hands are associated with interstitial lung disease in myositis patients regardless of the presence of antisynthetase antibodies. Rheumatology (Oxford) 2023 (Online ahead of print).
- Faghihi-Kashani S, Yoshida A, Bozan F, et al. Clinical characteristics of anti-synthetase syndrome: analysis from the Classification Criteria for Anti-Synthetase Syndrome Project. Arthritis Rheumatol 2024 (Online ahead of print).
- Monti S, Montecucco C, Cavagna L. Clinical spectrum of anti-Jo-1-associated disease. Curr Opin Rheumatol 2017; 29:612-617.
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