Transient global amnesia (TGA): MRI features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Transient global amnesia (TGA): MRI features. These are transient or vanishing lesions in the hippocampus. Fully referenced neurology checklist.

Hippocampal punctate DWI lesions (HPDL)

  • These are transient or vanishing lesions in the hippocampus
  • Extra-hippocampal lesions may however also be seen (E-HPDL)
  • They are most evident within 12-24 hours of onset of TGA
  • They may be visible up to 6 days after
  • The MRI is however usually normal

Acronym

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References

  1. Webb AJS, Rothwell PM. Neurological picture. Transient global amnesia associated with bilateral restricted diffusion in the lateral hippocampus. JNNP 2013; 84:522.
  2. Szabo K, Hoyer C, Caplan LR, et al. Diffusion-weighted MRI in transient global amnesia and its diagnostic implications. Neurology 2020; 95:e206-e212.
  3. Wilkinson T, Geranmayeh F, Dassan P, Janssen JC. Neuroimaging in transient global amnesia. Pract Neurol 2013; 13:56-57.
  4. Li J, Hu WL. Bilateral hippocampal abnormalities in magnetic resonance imaging in transient global amnesia. Am J Emerg Med 2013; 31:755.e1-e3.
  5. Piffer S, Nannoni S, Maulucci F, et al. Transient global amnesia with unexpected clinical and radiological findings: A case series and systematic review. J Neurol Sci 2022; 441:120349.
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