Thymoma associated multi-organ autoimmunity (TAMA)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Thymoma associated multi-organ autoimmunity (TAMA). This is a graft-versus-host-disease (GVHD) like disorder. Fully referenced neurology checklist.
Pathology
- This is a graft-versus-host-disease (GVHD) like disorder
- It results from the activation of autoreactive T cells in patients with thymoma
- It involves multiple organs
Neurological features
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Haematological features
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Dermatological features
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Thyroid features
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Immunological features
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Anti-PIT-1 antibody syndrome
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Other features
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Treatment
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References
- Evoli A, Minisci C, Di Schino C, et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002; 59:1844-1850.
- Suzuki S, Utsugisawa K, Suzuki N. Overlooked non-motor symptoms in myasthenia gravis. JNNP 2013; 84:989-994.
- Bernard C, Frih H, Pasquet F, et al. Thymoma associated with autoimmune diseases: 85 cases and literature review. Autoimmun Rev 2016; 15:82-92.
- Mouyis M, Dollman G, Penn H, John L, Hamdulay S. Is it lupus? TAMA: an important multi-system autoimmune disease entity physicians need to consider. QJM 2016; 109:687-688.
- Tomaszek S, Wigle DA, Keshavjee S, Fischer S. Thymomas: review of current clinical practice. Ann Thorac Surg 2009; 87:1973-1980.
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