Myasthenia gravis (MG) with thymoma
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Myasthenia gravis (MG) with thymoma. Thymomas are present in 15% of MG. Fully referenced neurology checklist.
Pathology
- Thymomas are present in 15% of MG
- They are microscopic in 4% of cases: with diameter <1mm
- They are often invasive and cause severe myasthenia
- They are medullary, mixed, cortical, or well-differentiated carcinomas
- The thymomas may be extra-thymic
Myasthenia gravis antibodies associated with thymoma
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Features of MG associated with thymoma
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Other neurological manifestations of thymoma
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Other thymic pathologies associated with MG
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References
- Evoli A, Minisci C, Di Schino C, et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002; 59:1844-1850.
- Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2010; 17:893-902.
- Vaideeswar P. Microscopic thymoma: a report of four cases with review of literature. Indian J Pathol Microbiol 2011; 54:539-541.
- Chalabreysse L, Orsini A, Vial C, Tronc F. Microscopic thymoma. Interact Cardiovasc Thorac Surg 2007; 6:133-135.
- Fukuhara M, Higuchi M, Owada Y, et al. Clinical and pathological aspects of microscopic thymoma with myasthenia gravis and review of published reports. J Thorac Dis 2017; 9:1592-1597.
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