Stiff person syndrome (SPS): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Stiff person syndrome (SPS): clinical features. The onset is typically in the 4th to 6th decade. Fully referenced neurology checklist.
Epidemiology
- The onset is typically in the 4th to 6th decade
- Females predominate 2:1
- Symptoms improve in pregnancy
Features of rigidity
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Features of spasms
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Other features
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Associated autoimmune disorders
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Associated cancers
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Differential diagnoses
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Red flags against SPS diagnosis
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SPS in pregnancy
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Outcome
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References
- Lockman J, Burns TM. Stiff person syndrome. Pract Neurol 2007; 7:106-108.
- Hadavi S, Noyce AJ, Leslie RD, Giovannoni G. Stiff person syndrome. Pract Neurol 2011; 11:272-282.
- Esch ME, Newsome SD. Improvement of stiff-person syndrome symptoms in pregnancy: case series and literature review. Neurol Neuroimmunol Neuroinflamm 2020; pii: e684.
- Dalakas MC. Stiff person syndrome: advances in pathogenesis and therapeutic interventions. Curr Treat Options Neurol 2009; 11:102-110.
- Benavides DR, Newsome SD. Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome. Neurol Neuroimmunol Neuroinflamm 2016; 3:e281.
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