Stiff person spectrum disorder (SPSD) phenotype
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Stiff person spectrum disorder (SPSD) phenotype. The sphincters are involved in half of cases. Fully referenced neurology checklist.
Stiff limb syndrome
- The sphincters are involved in half of cases
- The brainstem is involved in a third of cases
- Most are anti-GAD antibody negative
Stiff person syndrome (SPS) plus: types
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Stiff person syndrome (SPS) with encephalomyelitis
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Other SPS variants
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Proposed diagnostic criteria
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References
- Lockman J, Burns TM. Stiff person syndrome. Pract Neurol 2007; 7:106-108.
- Chia NH, McKeon A, Dalakas MC, et al. Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria. Ann Clin Transl Neurol 2023 (Online ahead of print).
- Hadavi S, Noyce AJ, Leslie RD, Giovannoni G. Stiff person syndrome. Pract Neurol 2011; 11:272-282.
- Dalakas MC. Stiff person syndrome: advances in pathogenesis and therapeutic interventions. Curr Treat Options Neurol 2009; 11:102-110.
