Sleeping sickness: peripheral features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Sleeping sickness: peripheral features. Diffuse hyperpathia, Painful hyperaesthesia. Fully referenced neurology checklist.

Peripheral neuropathy (PN): manifestations

  • Diffuse hyperpathia
  • Painful hyperaesthesia
  • Kerandel's sign: this is deep hyperaesthesia
  • Fasciculations: in the tongue and limbs

Dermatological features

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Lymphadenopathy

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Systemic features

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Synonyms

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References

  1. Dzikowiec M, Góralska K, Błaszkowska J. Neuroinvasions caused by parasites. Ann Parasitol 2017; 63:243–253.
  2. Malvy D, Chappuis F. Sleeping sickness. Clin Microbiol Infect 2011; 17:986-995. 
  3. Ehrhardt S, Lippert U, Burchard GD, Sudeck H. Orchitis as an unusual manifestation of human African trypanosomiasis. J Infect 2006; 52:e31-e33. 
  4. Stich A, Abel PM, Krishna S. Human African trypanosomiasis. BMJ 2002; 325:203-206. 
  5. Kennedy PG. Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 2004; 113:496-504. 

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