Sleeping sickness: management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Sleeping sickness: management. The Card Agglutination Test for Trypanosomiasis (CATT), Immunofluorescence, ELISA. Fully referenced neurology checklist.

Screening tests

  • The Card Agglutination Test for Trypanosomiasis (CATT)
  • Immunofluorescence
  • ELISA

Parasitological confirmation

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Cerebrospinal fluid (CSF) analysis

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Magnetic resonance imaging (MRI) brain: features

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Electroencephalogram (EEG)

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Treatment for Gambiense

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Treatment for Rhodesiense

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Synonyms

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References

  1. Dzikowiec M, Góralska K, Błaszkowska J. Neuroinvasions caused by parasites. Ann Parasitol 2017; 63:243–253.
  2. Malvy D, Chappuis F. Sleeping sickness. Clin Microbiol Infect 2011; 17:986-995. 
  3. Ehrhardt S, Lippert U, Burchard GD, Sudeck H. Orchitis as an unusual manifestation of human African trypanosomiasis. J Infect 2006; 52:e31-e33. 
  4. Kennedy PG. Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 2004; 113:496-504. 

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