Sepsis associated encephalopathy (SAE): pathology
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Sepsis associated encephalopathy (SAE): pathology. This is diffuse brain dysfunction secondary to infection outside the central nervous system.
Pathology
- This is diffuse brain dysfunction secondary to infection outside the central nervous system
- It develops in 50-70% of people with sepsis
Pathophysiological mechanisms
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Frequently associated organisms
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Synonym
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References
- Gofton TE, Young GB. Sepsis-associated encephalopathy. Nat Rev Neurol 2012; 8:557-566.
- Chen J, Shi X, Diao M, et al. A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes. BMC Emerg Med 2020; 20:77.
- Gao Q, Hernandes MS. Sepsis-associated encephalopathy and blood-brain barrier dysfunction. Inflammation 2021 (Online ahead of print).
- Catarina AV, Branchini G, Bettoni L, De Oliveira JR, Nunes FB. Sepsis-associated encephalopathy: from pathophysiology to progress in experimental studies. Mol Neurobiol 2021; 58:2770-2779.
- Tauber SC, Djukic M, Gossner J, Eiffert H, Brück W, Nau R. Sepsis-associated encephalopathy and septic encephalitis: an update. Expert Rev Anti Infect Ther 2021; 19:215-231.
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