Sepsis associated encephalopathy (SAE): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Sepsis associated encephalopathy (SAE): management. High serum lactate, High serum sodium, Low platelet count. Fully referenced neurology checklist.
Laboratory features
- High serum lactate
- High serum sodium
- Low platelet count
- Low serum albumin
Magnetic resonance imaging (MRI) brain: features
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Electroencephalogram (EEG): features
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Evoked potentials (EP)
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Cerebrospinal fluid (CSF) analysis
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Non-specific biomarkers
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Potential biomarkers
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Treatment
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Synonyms
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References
- Gofton TE, Young GB. Sepsis-associated encephalopathy. Nat Rev Neurol 2012; 8:557-566.
- Chung HY, Wickel J, Brunkhorst FM, Geis C. Sepsis-associated encephalopathy: from delirium to dementia? J Clin Med 2020; 9:703.
- Ahmed M, Sureka J, Mathew V, Jakkani RK, Abhilash KP. Magnetic resonance imaging findings in a fatal case of Salmonella typhi-associated encephalopathy: a case report and literature review. Neurol India 2011; 59:270-272.
- Shindo A, Suzuki K, Iwashita Y, Tomimoto H. Sepsis-associated encephalopathy with multiple microbleeds in cerebral white matter. Am J Med 2018; 131:e297-e298.
- Hosokawa K, Gaspard N, Su F, Oddo M, Vincent JL, Taccone FS. Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review. Crit Care 2014; 18:674.
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